Edinger-westphal Nucleus Information
The Edinger-Westphal nucleus (also known as the accessory oculomotor nucleus ) is the accessory parasympathetic cranial nerve nucleus of the oculomotor nerve (cranial nerve III), supplying the constricting muscles of the iris. Alternatively, the Edinger-Westphal nucleus is a term often used to refer to the adjacent population of non-preganglionic neurons that do not project to the ciliary ganglion, but rather project to the spinal cord, dorsal raphe nucleus, and lateral septal nuclei. Unlike the classical, preganglionic Edinger-Westphal neurons that contain choline acetyltransferase, neurons of the non-preganglionic Edinger-Westphal nucleus have been shown to contain various stress- and feeding-related neuropeptides, such as Urocortin and cocaine- and amphetamine-regulated transcript.[1] Recently a proposal to rename this group of non-preganglionic, neuropeptide-containing neurons to perioculomotor subgriseal neuronal stream, abbreviated pIIISG, has been suggested.[2]
Contents |
Location
The paired nuclei are posterior to the main motor nucleus (oculomotor nucleus) and anterolateral to the cerebral aqueduct in the rostral midbrain at the level of the superior colliculus.
It is the most rostral of the parasympathetic nuclei in the brain stem.
Function
The Edinger-Westphal nucleus supplies preganglionic parasympathetic fibers to the eye, constricting the pupil, accommodating the lens, and convergence of the eyes.[3]
It has also been implicated in the mirroring of pupil size in sad facial expressions. When seeing a sad face, participants' pupils dilated or constricted to mirror the face they saw, which predicted both how sad they perceived the face to be, as well as activity within this region.[4][5]
Eponym
The nucleus is named for both Ludwig Edinger, from Frankfurt, who demonstrated it in the fetus in 1885, and for Karl Friedrich Otto Westphal, from Berlin, who demonstrated it in the adult in 1887.[6]
Additional images
|
The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue. |
Nuclei of origin of cranial motor nerves schematically represented; lateral view. |
Primary terminal nuclei of the afferent (sensory) cranial nerves schematically represented; lateral view. |
References
- ^ Kozicz, T. (2003). "Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat". Neuroscience 116 (2): 315–20. doi:10.1016/S0306-4522(02)00772-8. PMID 12559087.
- ^ May PJ, Reiner AJ, Ryabinin AE (March 2008). "Comparison of the distributions of urocortin-containing and cholinergic neurons in the perioculomotor midbrain of the cat and macaque". J. Comp. Neurol. 507 (3): 1300–16. doi:10.1002/cne.21514. PMID 18186029.
- ^ "eye, human" Encyclopædia Britannica. Encyclopaedia Britannica Ultimate Reference Suite. Chicago: Encyclopædia Britannica, 2010.
- ^ Harrison, NA; Wilson, CE; Critchley, HD (2007). "Processing of observed pupil size modulates perception of sadness and predicts empathy.". Emotion (Washington, D.C.) 7 (4): 724–9. doi:10.1037/1528-3542.7.4.724. PMID 18039039.
- ^ Harrison, NA; Singer, T; Rotshtein, P; Dolan, RJ; Critchley, HD (2006). "Pupillary contagion: central mechanisms engaged in sadness processing.". Social cognitive and affective neuroscience 1 (1): 5–17. doi:10.1093/scan/nsl006. PMID 17186063. PMC 1716019. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1716019&blobtype=pdf.
- ^ synd/893 at Who Named It?
External links
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||
Categories: Neuroanatomy
|